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Posts Tagged ‘PDE5’

What is Erectile Dysfunction

Erectile dysfunction is incredibly common and millions of men suffer from it worldwide. Often known as male impotence, erectile dysfunction is when a man struggles to gain and maintain an erection which prevents him from having a regular and enjoyable sex life. The effects on a man’s confidence and relationships can be extreme, erectile dysfunction affects men in different ways. There are various causes for erectile dysfunction. Many psychological causes include stress, lack of confidence, anxiety, and so on. Physiological causes are also common.

When the male body is sexually aroused two chemicals are produced0 cyclic GMP, which causes the muscles in the arterial wall of the penis to relax allowing an erection and phosphodiesterase type 5 (PDE-5, which decreases erections. Two chemicals are produced by the male body whilst sexually aroused - Cyclic GMP (cGMP ), which causes the muscles in the arterial wall of the penis to relax allowing blood to flow in and phosphodiesterase type 5 (PDE-5) which decreases erections. Treatments are available for erectile dysfunction that works by reducing inhibiting PDE-5 and allowing increased blood flow to a man’s penis. When a man then becomes sexually aroused the PDE5 is disabled and a man is able to get and maintain an erection as the cGMP does not break down and the blood is able to increase. This increases a man’s confidence and allowing him to enjoy a regular and healthy sex life.

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How Viagra works

Viagra is one of the most popular treatments for male erectile dysfunction. It comes in various forms and doses, and millions of men worldwide use it to fix their impotence and put the spice back into their sex life! Viagra works by eliminating enzyme phosphodiesterase-5 (PDE5) which decomposes cGMP in a mans penis. This allows cGMP to build up affecting the artery walls. The larger the amount of cGMP, the more blood flow can occur in the penis. Increased blood flow causes an erection, and so a man is able to gain and maintain an erection.

PDE5 is found primarily in the penis. It is an enzyme, this means it can speed up a chemical reaction in the body.

PDE5 accepts cGMP and in its reaction, reduces it. This makes an erection difficult. The chemical created by the pharmaceutical company that founded Viagra is called sildenafil citrate. This sildenafil citrate disables the PDE5 enzyme when it fits into it. When a man takes Viagra, sildenafil citrate affects the PDE5 enzyme. When a man then becomes sexually aroused the PDE5 is disabled and a man is able to get and maintain an erection as the cGMP does not break down and the blood is able to increase.

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